Time-Course Metabolomic Analysis: Production of Betaine Structural Analogs by Fungal Fermentation of Seaweed.
N. Inoue, K. Tsuge, T. Yanagita, A. Oikawa, K. Nagao, Metabolites, 14: 201 (2024) [PubMed]

Ozonated olive oil intake attenuates hepatic steatosis in obese db/db mice.
Y. Kato, M. Sakoh, T. Nagai, A. Yoshida, H. Ishida, N. Inoue, T. Yanagita, K. Nagao, J. Oleo Sci., 73: 231-237 (2024) [PubMed]

Identification of genes regulated by lipids from seaweed Susabinori (Pyropia yezoensis) involved in the improvement of hepatic steatosis: Insights from RNA-Seq analysis in obese db/db mice.
S. Iizasa , K. Nagao, K. Tsuge, Y. Nagano, T. Yanagita, PLoS One, 18(12): e0295591 (2023) [PubMed]

Absorption, metabolism, nutrition and function of lipids. [Article in Japanese]
K. Nagao, Oleoscience, 22: 514-520 (2022) [Publisher]

Functional lipids and metabolic syndrome. [Article in Japanese]
K. Nagao, J. Jpn. Asoc. Food Sci. Risk Anal, 17: 144-149 (2022) [Publisher]

Dried and fermented powders of edible algae (Neopyropia yezoensis) attenuate hepatic steatosis in obese mice.
K. Nagao, N. Inoue, K. Tsuge, A. Oikawa, T. Kayashima, T. Yanagita, Molecules, 27: 2640 (2022) [PubMed]

Comparison of lipoprotein cholesterol levels in golden Syrian hamster administrated trans-octadecenoic acid positional isomers.
K. Nagao, K. Yoshinaga, T. Nagai, H. Mizobe, A. Yoshida, F. Beppu, S. Tanaka, N. Gotoh, J. Oleo Sci., 71: 609-618 (2022) [PubMed]

Ozonated olive oil alleviates hepatic steatosis in obese Zucker (fa/fa) rats.
Y. Kato, M. Sakoh, T. Nagai, A. Yoshida, H. Ishida, N. Inoue, T. Yanagita, K. Nagao, J. Oleo Sci., 71: 599-607 (2022) [PubMed]

The cholesterol metabolite cholest-5-en-3-one alleviate hyperglycemia and hyperinsulinemia in obese (db/db) mice.
K. Nagao, N. Inoue, K. Suzuki, T. Shimizu, T. Yanagita, Metabolites, 12: 26 (2022) [PubMed]

Hydrophilic ƒÀ-conglycinin peptide reduces hepatic triglyceride accumulation in obese model OLETF rats.
S. Wanezaki, S. Saito, N. Inoue, N. Tachibana, T. Yanagita, K. Nagao, Food Sci. Technol. Res., 26: 797-803 (2020) [Publisher]

Anti-stress effects of rosemary (Rosmarinus officinalis L.) leaf extract on intestinal goblet cells and immobility of forced-swimming test in BALB/c mice.
T. Kayashima, K. Nagao, M. Umino, H. Kaikiri, S. Shibata, K. Matsubara, Biosci. Biotechnol. Biochem., 84: 2385-2389 (2020) [PubMed]

Eicosapentaenoic acid-containing polar lipids from seaweed Susabinori (Pyropia yezoensis) alleviate hepatic steatosis in obese db/db mice.
T. Yanagita, K. Tsuge, M. Koga, N. Inoue, K. Nagao, Archiv. Biochem Biophys., 691: 108486 (2020) [PubMed]

Soy ƒÀ-conglycinin peptide attenuates obesity and lipid abnormalities in obese model OLETF rats.
S. Wanezaki, S. Saito, N. Inoue, N. Tachibana, B. Shirouchi, M. Sato, T. Yanagita, K. Nagao, J. Oleo Sci., 69: 495-502 (2020) [PubMed]

Koji glycosylceramide commonly contained in Japanese traditional fermented foods alters cholesterol metabolism in obese mice.
H. Hamajima, M. Tanaka, M. Miyagawa, M. Sakamoto, T. Nakamura, T. Yanagita, M. Nishimukai, S. Mitsutake, J. Nakayama, K. Nagao, H. Kitagaki, Biosci. Biotechnol. Biochem., 83: 1514-1522 (2019) [PubMed]

Evaluating the content and distribution of trans fatty acid isomers in foods consumed in Japan.
N. Gotoh, K. Yoshinaga, S. Kagino, Y. Katoh, Y. MIzuno, F. Beppu, T. Nagai, H. Mizobe, A. Yoshida, K. Nagao, J. Oleo Sci., 68:193-202 (2019) [PubMed]

Metabolism of Natural Highly Unsaturated Fatty Acid, Tetracosahexaenoic Acid (24:6n-3), in C57BL/KsJ-db/db Mice.
N. Gotoh, K. Nagao, H. Ishida, K. Nakamitsu, K. Yoshinaga, T. Nagai, F. Beppu, H. Watanabe, T. Yanagita, J. Oleo Sci., 67:1597-1607 (2018) [PubMed]

Study on the trans fatty acid formation in oil by heating using model compounds.
N. Gotoh, S. Kagino, K. Yoshinaga, H. Mizobe,T. Nagai, A. Yoshida, F. Beppu, K. Nagao, J. Oleo Sci., 67: 273-281 (2018) [PubMed]

Comparison of the Effect of trans Fatty Acid Isomers on Apolipoprotein A1 and B Secretion in HepG2 Cells..
K. Nagao, K. Yoshinaga, T. Nagai, H. Mizobe, A. Yoshida, F. Beppu, N. Gotoh J. Oleo Sci., 66: 1175-1181 (2017) [PubMed]

Development of a quantitative method for the contents of glycosylceramide contained in Japanese foods brewed with koji and its application. [Article in Japanese]
M. Sakamoto, M. Sakatani, J. Ferdouse, H. Hamajima, K. Tsuge, M. Nishimukai, T. Yanagita, K. Nagao, S. Mitsutake, H. Kitagaki, J. Brew. Soc. Japan, 112: 655-662 (2017) [Publisher]

Pterostilbene, a dimethylated analog of resveratrol, promotes energy metabolism in obese rats.
K. Nagao, T. jinnouch, S. Kai, T. Yanagita, J. Nutr. Biochem, 43: 151-155 (2017) [PubMed]

Soy Protein Isolate Suppresses Lipodystrophy-induced Hepatic Lipid Accumulation in Model Mice.
K. Nagao, A. Matsumoto, S. Kai, T. Kayashima, T. Yanagita, J. Oleo Sci., 66: 161-169 (2017) [PubMed]

Japanese Traditional Dietary Fungus Koji Aspergillus Oryzae Functions as a Prebiotic for Blautia Coccoides through Glycosylceramide.
H. Hamajima, H. Matsunaga, A. Fujikawa, T. Sato, S. Mitsutake, T. Yanagita, K. Nagao, J. Nakayama, H. Kitagaki, Springerplus, 5: 1321 (2016) [PubMed]

Prevention and aleviation of metabolic syndrome by food environment. [Article in Japanese]
K. Nagao, T. Yanagita, Atherosclerosis, ed. by T. Toda, ATMS, 134-142 (2016) [Publisher]

Probiotic Lactobacillus gasseri SBT2055 improves glucose tolerance and reduces body weight gain in rats by stimulating energy expenditure.
B. Shirouchi, K. Nagao, M. Umegatani, A. Shiraishi, Y. Morita, S. Kai, T. Yanagita, A. Ogawa, Y. Kadooka, M. Sato, Br. J. Nutr., 116: 451-458 (2016) [PubMed]

Chemical analysis of the sugar moiety of monohexosylceramide contained in koji, Japanese traditional rice fermented with Aspergillus.
H. Hamajima, H. Matsunaga, M. Yamashiro, S. Tan, S. Kumagai, N. Hayashi, K. Nagao, S. Mitsutake, H. Kitagaki, Fermentation, 2: 2 (2016) [Publisher]

Trans-octadecenoic Acid Positional Isomers Have Different Accumulation and Catabolism Properties in Mice.
F. Beppu, M. Asanuma, Y. Kawamura, T. Nagai, K. Yoshinaga, H. Mizobe, K. Kojima, S. Kasatani, K. Nagao, A. Kubo, J. Kanda, N. Gotoh, J. Oleo Sci., 64: 1159-1167 (2015) [PubMed]

Generation of tetracosahexaenoic acid in marine organisms.
R. Suo, H. Li, K. Yoshinaga, T. Nagai, H. Mizobe, K. Kojima, K. Nagao, F. Beppu, N. Gotoh, J. Oleo Sci., 64: 721-727 (2015) [PubMed]

Glucosylceramide Contained in Koji Mold-Cultured Cereal Confers Membrane and Flavor Modification and Stress Tolerance to Saccharomyces cerevisiae during Coculture Fermentation.
K. Sawada, T. Sato, H. Hamajima, L. Jayakody, M. Hirata, M. Yamashiro, M. Tajima, S. Mitsutake, K. Nagao, K. Tsuge, F. Abe, K. Hanada,.H. Kitagaki, Appl. Environ. Microb., 81: 3688-3698 (2015) [PubMed]

Functional lipids in metabolic syndrome.
K. Nagao, T. Yanagita, J. Nutr. Sci. Vitaminol., 61: S159-161 (2015) [PubMed]

Soy ƒÀ-conglycinin improves obesity-induced metabolic abnormalities in a rat model of nonalcoholic fatty liver disease.
S. Wanezaki, N. Tachibana, M. Nagata, S. Saito, K. Nagao, T. Yanagita, M. Kohno, Obes. Res. Clin. Prac., 9: 168-174 (2015) [PubMed]

Differential effects of triacylglycerol positional isomers containing n-3 series highly unsaturated fatty acids on lipid metabolism in C57BL/6J mice.
K. Yoshinaga, K. Sasaki, H. Watanabe, K. Nagao, N. Inoue, B. Shirouchi, T. Yanagita, T. Nagai, H. Mizobe, K. Kojima, F. Beppu, N. Gotoh, J. Nutr. Biochem., 26: 57-63 (2015) [PubMed]

Nutrition and metabolism of lipids. [Article in Japanese]
K. Nagao, Oleoscience, 14: 563-567 (2014) [Publisher]

A comparison of the lipid-lowering effects of four different n-3 highly unsaturated fatty acids in HepG2 cells.
K. Nagao, K. Nakamitsu, H. Ishida, K. Yoshinaga, T. Nagai, H. Mizobe, K. Kojima, T. Yanagita, F. Beppu, N. Gotoh, J. Oleo Sci., 63: 979-985 (2014) [PubMed]

Impact of fasting time on hepatic lipid metabolism in nutritional animal studies.
I. Ikeda, K. Metokia, T. Yamahiraa, M. Kato, N. Inoue, K. Nagao, T. Yanagita, H. Shirakawa, M. Komai, Biosci. Biotechnol. Biochem., 78: 1584-1591 (2014) [PubMed]
*This publication was given an Award for Excellence to Authors Publishing in Biosci. Biotechnol. Biochem. in 2014.

Structural determination by electrospray ionization tandem mass spectrometry (ESI-MS/MS) of glucosylceramides in the distillate of potato shoshu, the traditional Japanese liquor produced from sweet potato. [Article in Japanese]
K. Sawada, E. Nakahata1, Keisuke Tsuge, Miyo Hirata, Kazunori Takamine, K. Nagao, H. Kitagaki, J. Brew. Soc. Japan, 109: 535-542 (2014) [Publisher]

Unavailability of liver triacylglycerol increases serum cholesterol concentration induced by dietary cholesterol in exogenously hypercholesterolemic (ExHC) rats.
Y. Tanaka, K. Nagao, H. Nakagiri, T. Nagaso, Y. Iwasa, H. Mori, M. Asahina, K. Imaizumi, M. Sato, Lipids Health Dis., 13: 19 (2014) [PubMed]

Quantitaion and structural determination of glucosylceramides contained in sake lees.
K. Takahashi, K. Izumi, E. Nakahata, M. Hirata, K. Sawada, K. Tsuge, K. Nagao, H. Kitagaki, J. Oleo Sci., 63: 15-23 (2014) [PubMed]

Dietary phosphatidylinositol protects C57BL/6 mice from concanavalin A-induced liver injury by modulating immune cell functions.
M. Inafuku, K. Nagao, A. Inafuku, T. Yanagita, N. Taira, T. Toda, H. Oku, Mol. Nutr. Food Res., 57: 1671-1679 (2013) [PubMed]

Effect of Mukitake mushroom (Panellus serotinus) on the pathogenesis of lipid abnormalities in obese, diabetic ob/ob mice.
N. Inoue, M. Inafuku, B. Shirouchi, K. Nagao, T. Yanagita, Lipids Health Dis., 12: 18 (2013) [PubMed]

Nutritional functions of omega3-fatty acids.[Article in Japanese]
K. Nagao BIO INDUSTRY 30, 5-10 (2013) [Publisher]

Effect of dietary resveratrol on the metabolic profile of nutrients in obese OLETF rats.
K. Nagao, T. Jinnouchi, S. Kai, T. Yanagita, Lipids Health Dis., 12: 8 (2013) [PubMed]

Dietary fats and health. [Article in Japanese]
T. Yanagita, K. Nagao, SHIBOU NO KOUZAI TO KENKOU, 29-47 (2013) [Publisher]

Structural Determination of Glucosylceramides in the Distillation Remnants of Shochu, the Japanese Traditional Liquor, and Its Production by Aspergillus kawachii.
M. Hirata, T. Tsuge, L. Jayakody, Y. Urano, K. Takahashi, K. Sawada, S. Inaba, K. Nagao, H. Kitagaki, J. Agric. Food Chem., 60: 11473-11482 (2012) [PubMed]

Mechanisms underlying the decreased hepatic triacylglycerol and cholesterol by dietary bitter melon extract in the rat.
GV. Senanayake, N. Fukuda, S. Nshizono, YM. Wang, K. Nagao, T. Yanagita, M. Iwamoto, H. Ohta, Lipids, 47: 495-503 (2012) [PubMed]

Functional lipids in metabolic syndrome. [Article in Japanese]
K. Nagao, J. Anal. Bio-Sci., 35: 113-118 (2012)

Effects of lotus root (edible rhizome of Nelumbo nucifera) on the deveolopment of nonalcoholic fatty liver disease in obese diabetic db/db mice.
Y. Tsuruta, K. Nagao, B. Shirouchi, S. Nomura, K. Tsuge, K. Koganemaru, T. Yanagita, Biosci. Biotechnol. Biochem., 76: 462-466 (2012) [PubMed]

Protective effects of fractional extracts from Panellus serotinus on nonalcoholic fatty liver disease in obese, diabetic db/db mice.
M. Inafuku, K. Nagao, S. Nomura, B. Shirouchi, N. Inoue, N. Nagamori, H. Nakayama, T. Toda, T. Yanagita, Br. J. Nutr., 107: 639-646 (2012) [PubMed]

Polyphenolic extract of lotus root (edible rhizome of Nelumbo nucifera) alleviates hepatic steatosis in obese diabetic db/db mice.
Y. Tsuruta, K. Nagao, S. Kai, T. Yoshimura, K. Tsuge, K. Koganemaru, T. Yanagita, Lipids Health Dis., 10: 202 (2011) [PubMed]

Effect of liver X receptor agonist on deposition and lymphatic absorption of plant sterols in stroke-prone spontaneously hypertensive rats that have a mutation in ATP-binding cassette transporter g5.
T. Hamada, M. Kudo, M. Sato, N. Inoue, K. Nagao, K. Imaizumi, I. Ikeda, Biosci. Biotechnol. Biochem., 75: 2359-2363 (2011) [PubMed]

Effect of Vaccinium ashei reade leaf extracts on lipid metabolism in obese OLETF rats.
N. Inoue, K. Nagao, S. Nomura, B. Shirouchi, M. Inafuku, H. hirabaru, N. Nakahara, S. Nishizono, T. Tanaka, T. Yanagita, Biosci. Biotechnol. Biochem., 75: 2304-2308 (2011) [PubMed]

Screening of soy protein-derived hypotriglyceridemic di-peptides in vitro and in vivo.
N. Inoue, K. Nagao, K. Sakata, N. Yamano, PER. Gunawardena, SY Han, T. Matsui, T. Nakamori, H. Furuta, K. Takamatsu, T. Yanagita, Lipids Health Dis., 10: 85 (2011) [PubMed]

Docosahexaenoic acid containing phosphatidylcholine alleviates obesity-related disorders in obese rats.
B. Shirouchi, K. Nagao, T. Yanagita, Omega-3 Oils: Applications in Functional Foods, ed. by EM. Hernandez, M. Hosokawa, AOCS press, USA, 205-212, (2011) [Publisher]

Anti-metabolic syndrome effects of Panellus serotinus. [Article in Japanese]
T. Yanagita, K. Nagao, New Food Industry, 52: 13-17 (2010)

Physiological effects of dietary PIPS soybean-derived phospholipid in obese Zucker (fa/fa) rats.
B. Shirouchi, K. Nagao, K. Furuya, M. Shiojiri, X. Liu, T. Yanagita, Biosci. Biotechnol. Biochem., 74: 2333-2335 (2010) [PubMed]

Effects of citrus auraptene (7-geranyloxycoumarin) on hepatic lipid metabolism in vitro and in vivo.
K. Nagao, N. Yamano, B. Shirouchi, N. Inoue, S. Murakami, T. Sasaki, T. Yanagita, J. Agric. Food Chem., 58: 9028-9032 (2010) [PubMed]

Dietary phosphatidylinositol in metabolic syndrome.
B. Shirouchi, K. Nagao, T. Yanagita, Biocatalysis and Biomolecular Engineering , ed. by C.T. Hou, J.F. Shaw, John Wiley & Sons, Inc., USA, 165-174 (2010) [Publisher]

Physiological Functions of iso-type Short-Chain Fatty Acid and Omega 3 Polyunsaturated Fatty Acids Containing Oil in Obese OLETF Rats.
B. Shirouchi, K. Nagao, K. Furuya, T. Nagai, K. Ichioka, S. Tokairin, Y. Iida, T. Yanagita , J. Oleo Sci., 59: 299-305 (2010) [PubMed]

Mukitake mushroom (Panellus serotinus) alleviates nonalcoholic fatty liver disease through the suppression of monocyte chemoattractant protein 1 production in db/db mice.
K. Nagao, N. Inoue, M. Inafuku, B.Shirouchi, T. Morooka, S.Nomura, N. Nagamori, T. Yanagita, J. Nutr. Biochem., 21: 418-423 (2010) [PubMed]

Dietary saponins of sea cucumber alleviate orotic acid-induced fatty liver in rats via PPAR alpha and SREBP-1c signaling.
XQ. Hu, YM. Wang, JF. Wang, Y. Xue, ZJ. Li, K. Nagao, T. Yanagita, CH. Xue, Lipids Health Dis.,9:25 (2010) [PubMed]

Medium-chain fatty acids: Functional lipids for the prevention and treatment of the metabolic syndrome.
K. Nagao, T. Yanagita, Pharmacol. Res., 61: 208-212 (2010) [PubMed]

Prevention of the metabolic syndrome with functional lipids. [Article in Japanese]
K. Nagao, J. Jpn. Soc. Nutr. Food Sci., 63: 3-7 (2010)

Effect of Three Kinds of Highly Purified n-3 Series Highly Unsaturated Fatty Acids on Lipid Metabolism in C57BL/KsJ-db/db Mice.
N. Gotoh, K.Nagao, S. Onoda, B. Shirouchi, K. Furuya, T. Nagai, H. Mizobe, K. Ichioka, H. Watanabe, T. Yanagita and S. Wada, J. Agric. Food Chem., 57: 11047-11054 (2009) [PubMed]

Dietary soy protein isolate and its undigested high molecular fraction upregulate hepatic ATP-binding cassette transporter G5 and ATP-binding cassette transporter G8 mRNA and increase biliary secretion of cholesterol in rats.
I. Ikeda, M. Kudo, T. Hamada, K. Nagao, Y. Oshiro, M. Kato, T. Sugawara, T. Yamahira, H. Ito, S. Tamaru, M. Sato, K. Imaizumi, S. Nagaoka, T. Yanagita, J. Nutr. Sci. Vitaminol., 55: 252-256 (2009) [PubMed]

Linoleic acid-menthyl ester reduces the secretion of apolipoprotein B100 in HepG2 cells.
N. Inoue, N. Yamano, K. Sakata, K. Arao, T. Kobayashi, T. Nagao, Y. Shimada, K. Nagao, T. Yanagita, J. Oleo Sci., 58: 171-175 (2009) [PubMed]

The sulfated polysaccharide porphyran reduces apolipoprotein B100 secretion and lipid synthesis in HepG2 cells.
N. Inoue, N. Yamano, K. Sakata, K. Nagao, Y. Hama, T. Yanagita, Biosci. Biotechnol. Biochem., 73: 447-449 (2009) [PubMed]

Effect of dietary phosphatidylinositol on cholesterol metabolism in Zucker (fa/fa) rats.
B. Shirouchi, K. Nagao, K. Furuya, N. Inoue, M. Inafuku, M. Nasu, K. Otsubo,S. Koga, H. Matsumoto, T. Yanagita, J. Oleo Sci., 58: 111-115 (2009) [PubMed]

Problems in the clinical application of conjugated linoleic acid. [Article in Japanese]
T. Yanagita, K. Nagao, The Lipid, 20: 78-81 (2009)

Cholesterol lowering effect of sulfur-containing amino acids added to a soybean protein diet in rats.
M. Taniguchi, K. Nagao, K. Inoue, K. Imaizumi, J. Nutr. Sci. Vitaminol., 54: 448-453 (2008) [PubMed]

Taurine reduces the secretion of apolipoprotein B100 and lipids in HepG2 cells.
T. Yanagita, S.Y. Han, Y. Hu, K. Nagao , H. Kitajima, S. Murakami, Lipids Health Dis.,7:38 (2008) [PubMed]

Prevention and alleviation of metabolic syndrome with functional lipids. [Article in Japanese]
K. Nagao, T. Yanagita, Kagaku to kougyo, 493-498 (2008)

Evaluation of the physiological function of docosahexaenoic acid in diet-induced lipodystrophy model mice.
T. Yanagita, K. Nagao, Biocatalysis and Bioenergy, ed. by C.T. Hou, J.R. Shaw, John Wiley & Sons, Inc., USA, 405-415 (2008)

Effect of Vaccinium ashei reade leaves on lipid metabolism in Otsuka Long-Evans Tokushima Fatty rats.
K. Nagao, K. Higa, B. Shirouchi, S. Nomura, N. Inoue, M. Inafuku, T. Yanagita, Biosci. Biotechnol. Biochem., 72: 1619-1622 (2008) [PubMed]

Physiological effect of conjugated linoleic acid. [Article in Japanese]
T. Yanagita, K. Nagao, Shokuhin kinousei no kagaku, 555-558 (2008)

Dietary phosphatidylinositol prevents the development of nonalcoholic fatty liver disease in Zucker (fa/fa) rats.
B. Shirouchi, K. Nagao, N. Inoue, K. Furuya, S. Koga, H. Matsumoto, T. Yanagita, J. Agrc. Food Chem., 56: 2375-2379 (2008) [PubMed]

Effect of leptin infusion on insulin sensitivity and lipid metabolism in diet-induced lipodystrophy model mice.
K. Nagao , N. Inoue , Y. Ujino , K. Higa , B. Shirouchi , Y.M. Wang, T. Yanagita, Lipids Health Dis.,7:8 (2008) [PubMed]

Bioactive lipids in metabolic syndrome.
K. Nagao, T. Yanagita, Prog. Lipid Res., 47: 127-146 (2008) [PubMed]
*This publication was given an Elsevier Top Cited Article 2008-2010 Award.

Functional lipids and the prevention of the metabolic syndrome.
T. Yanagita, K. Nagao, Asia Pac. J. Clin. Nutr., 17: 189-191 (2008) [PubMed]

Biological effects of conjugated-linoleic acid.
YS. Huang, T. Yanagita, K. Nagao, K. Koba, Fatty Acids in Foods and Their Health Implications III., ed. by C.K. Chow, CRC press, USA, 825-836 (2007)

Novel physiological functions of phospholipids. [Article in Japanese]
B. Shirouchi, K. Nagao, T. Yanagita, Foods Research, 630: 32-35 (2007)

Effect of Vaccinium ashei reade leaves on angiotensin converting enzyme activity in vitro and on systolic blood pressure of spontaneously hypertensive rats in vivo.
H. Sakaida, K. Nagao, K. Higa, B. Shirouchi, N. Inoue, F. Hidaka, T. Kai, T. Yanagita, Biosci. Biotechnol. Biochem.71, 2335-2337 (2007) [PubMed]

Effect of dietary omega3-PC on obesity-related disorders in obese OLETF rats.
B. Shirouchi, K. Nagao, N. Inoue, T. Ohkubo, H. Hibino, T. Yanagita, J. Agrc. Food Chem., 55, 7170-7176 (2007)
*This publication was given an AOCS Phospholipid Division Award for Best Papar.

[PubMed]

Application of CLA bioactivity. [Article in Japanese]
N. Inoue, K. Nagao, T. Yanagita, Foodstyle21, 11: 49-51 (2007)

Dietary soy protein increases mRNA expression of ABCG5 and ABCG8 in liver and biliary output of cholesterol in rats. [Article in Japanese]
I. Ikeda, M. Kudo, K. Nagao, T. Hamada, Y. Oshiro, T. Sugawara, T. Yamahira, K. Imaizumi, T. Yanagita, Soy Protein Res., 9: 108-112 (2006)

Conjugated linoleic acid in hypertension.
T. Yanagita, K. Nagao, N. Inoue,YM. Wang, Advances in conjugated linoleic acid research, Vol.3., ed. by M.P. Yurawecz, J.K.G. Kramer, O. Gudmundsen, M.W. Pariza, S. Banni, AOCS press, USA, 171-181, (2006)

Dietary conjugated linoleic acid lowered tumor necrosis factor-alpha content and altered expression of genes-related to lipid metabolism and insulin sensitivity in the skeletal muscle of Zucker rats.
N. Inoue, K. Nagao, Y.M. Wang, H. Noguchi, B. Shirouchi, T. Yanagita, J. Agrc. Food Chem., 54:7935-7939, (2006) [PubMed]

Biofunctional lipids. [Article in Japanese]
T. Yanagita, I. Ikeda, K. Nagao, KASEAA, 44: 563-568 (2006)

Campest-5-en-3-one, an oxidized derivative of campesterol, activates PPAR-alpha, promotes energy consumption and reduces visceral fat deposition in rats.
I. Ikeda, R. Konno, T. Shimizu, T. Ide, N. Takahashi, T. Kawada, K. Nagao, N. Inoue, T. Yanagita, T. Hamada, Y. Morinaga, H. Tomoyori, K. Imaizumi, K. Suzuki, Biochim. Biophys. Acta, 1760:800-807, (2006) [PubMed]

Dietary conjugated linoleic acid and metabolic syndromes.
K. Nagao, YM. Wang, N. Inoue, T. Yanagita, Dietary Fats and Risk of Chronic Disease., ed. by Y.S. Huang, T. Yanagita, H. Knapp, AOCS press, USA, 80-91, (2006)

Isomer-specific anti-obese and hypolipidemic properties of conjugated linoleic acid in obese OLETF rats.
YM. Wang , K. Nagao, N. Inoue, Y. Ujino, Y. Shimada, T. Nagao, T. Iwata, T. Kamegai, Y. Yamauchi-Sato, T. Yanagita, Biosci. Biotechnol. Biochem., 70:355-362, (2006) [PubMed]

Consumption of Pork-liver Protein Hydrolysate Reduces Body Fat in the Otsuka Long-Evans Tokushima Fatty Rats by Suppressing Hepatic Lipogenesis.
M. Shimizu, S. Tanabe, F. Morimatsu, K. Nagao, T. Yanagita, N. Kato, T. Nishimura, Biosci. Biotechnol. Biochem., 70:112-118, (2006) [PubMed]

Conjugated linoleic acid-induced fatty liver can be attenuated by combination with docosahexaenoic acid in C57BL/6N mice.
T. Yanagita, YM. Wang, K. Nagao, Y. Ujino, N. Inoue, J. Agrc. Food Chem., 53: 9629-9633, (2005) [PubMed]

Short-term feeding of conjugated linoleic acid does not induce hepatic steatosis in C57BL/6J mice.
YM. Wang, K. Nagao, Y. Ujino, K. Sakata, K. Higa, N. Inoue, T. Yanagita, J. Nutr. Sci. Vitaminol., 51: 440-444, (2005) [PubMed]

Conjugated fatty acids in food and their health benefits.
K. Nagao, T. Yanagita, J. Biosci. Bioeng., 100:152-157, (2005) [PubMed]

Dietary Phosphatidylcholine alleviates fatty liver induced by orotic acid.
Y. Buang, YM. Wang, JY. Cha, K. Nagao, T. Yanagita, Nutrition, 21:867-873, (2005) [PubMed]

Dietary gallate esters of tea catechins reduce deposition of visceral fat, hepatic triacylglycerol, and activities of hepatic enzymes related to Fatty Acid synthesis in rats.
I. Ikeda, R. Hamamoto, K. Uzu, K. Imaizumi, K. Nagao, T. Yanagita, Y. Suzuki, M. Kobayashi, T.Kakuda, Biosci. Biotechnol. Biochem., 69:1049-1053, (2005) [PubMed]

Dietary conjugated linoleic acid alleviates nonalcoholic fatty liver disease in Zucker (fa/fa) rats.
K. Nagao, N. Inoue, YM. Wang, B. Shirouchi, T. Yanagita, J. Nutr., 135: 9-13, (2005) [PubMed]

Physiological function of conjugated fatty acids. [Article in Japanese]
T. Yanagita,YM. Wang, K. Nagao, Functional Marine Lipids, 133-144 (2004)

The 9cis,11trans,13cis isomer of conjugated linolenic acid reduces apolipoprotein B100 secretion and triacylglycerol synthesis in HepG2 cells.
K. Arao, H. Yotsumoto, SY. Han, K. Nagao, T. Yanagita, Biosci. Biotechnol. Biochem., 68:2643-2645, (2004) [PubMed]

Dietary effect of pomegranate seed oil rich in 9cis,11trans,13cis conjugated linolenic acid on lipid metabolism in obese, hyperlipidemic OLETF Rats.
K. Arao, YM. Wang, N. Inoue, J. Hirata, JY. Cha, K. Nagao, T. Yanagita, Lipids Health Dis.,3:24, (2004) [PubMed]

Conjugated linoleic acid prevents the development of essential hypertension in spontaneously hypertensive rats.
N. Inoue , K. Nagao, J. Hirata, YM. Wang, T. Yanagita, Biochem. Biophys. Res. Commun., 323: 679-684, (2004) [PubMed]

Alleviation of Fatty Liver by alpha-Linolenic Acid.
Y. Buang , JY. Cha, K. Nagao, YM. Wang, N. Inoue, T. Yanagita, J. Nutr. Sci. Vitaminol., 50: 272-276, (2004) [PubMed]

Physiological functions of conjugated linoleic acid. [Article in Japanese]
K. Nagao, T. Yanagita, J. Jpn.Soc. Nutr. Food Sci., 57: 105-109 (2004)

Effects of conjugated linoleic acid isomers on obesity and lipid metabolism in obese rats.
T. Yanagita, K. Nagao, YM. Wang, Essential Fatty Acids and Eicosanoids, ed. by Y.S. Huang, S.J. Lin, P.C. Huang, AOCS press, USA, 348-352, (2003)

Conjugated linoleic acid enhances plasma adiponectin level and alleviates hyperinsulinemia and hypertension in Zucker diabetic fatty (fa/fa) rats.
K. Nagao, N. Inoue, YM. Wang, T. Yanagita, Biochem. Biophys. Res. Commun., 310: 562-566 (2003) [PubMed]

The mechanism of anti-obese and hypolipidemic effects of conjugated linoleic acid. [Article in Japanese]
T. Yanagita, K. Nagao, J. JASSO , 9: 194-196 (2003)

Purification of conjugated linoleic acid isomers through a process including lipase-catalyzed selective esterification.
T. Nagao, Y. Yamauchi-Sato, A. Sugihara, T. Iwata, K. Nagao, T. Yanagita, S. Adachi, Y. Shimada, Biosci. Biotechnol. Biochem., 67: 1429-1433 (2003) [PubMed]

Identification of the genetic polymorphsims responsible for hypercholesterolemia in ExHC rats. [Article in Japanese]
M. Sato, M. Asahina, T. Nagaso, K. Nagao, K. Imaizumi, JCBL, 45: 258-261 (2003)

The 10trans,12cis isomer of conjugated linoleic acid suppresses the development of hypertension in Otsuka Long-Evans Tokushima Fatty rats.
K. Nagao, N. Inoue, YM. Wang, Y. Buang, J. Hirata, T. Nagao, Y. Shimada, T. Matsui, T. Yanagita, Biochem. Biophys. Res. Commun., 306: 134-138 (2003) [PubMed]

The 10trans,12cis isomer of conjugated linoleic acid promotes energy metabolism in OLETF rats.
K. Nagao, YM. Wang, N. Inoue, SY. Han, Y. Buang, T. Noda, N. Koda, H. Okamatsu, T. Yanagita, Nutrition, 19: 652-656 (2003) [PubMed]

Body fat reduction by conjugated linoleic acid. [Article in Japanese]
T. Yanagita, K. Nagao, The Food Industry, 46: 18-24 (2003)

Conjugated linoleic acid reduces hepatic microsomal triacylglycerol transfer protein activity and hepatic triacylglycerol mass in obese rats.
YM. Wang, SM. Rahman, K. Nagao, SY. Han, Y. Buang, JY. Cha, T. Yanagita, J. Oleo Sci., 52: 129-134 (2003) [Publisher]

Comparison of the effects of triacylglycerol-CLA and free fatty acid-CLA on hepatic lipid metabolism in OLETF obese rats.
YM. Wang, SM. Rahman, K. Nagao, K Arao, N. Inoue, T. Yanagita, J. Oleo Sci., 52: 121-128 (2003) [Publisher]

Sterol efflux to apolipoprotein A-I originates from caveolin-rich microdomains and potentiates PDGF-dependent protein kinase activity.
PE. Fielding, JS. Russel, TA. Spencer, H. Hakamata, K. Nagao, CJ. Fielding, Biochemistry, 41: 4929-4937 (2002) [PubMed]

S-Propyl-cystein sulfoxide and DL-methionine sulfoxide inhibit the secretion of apolipoprotein B100 secretion and lipids in HepG2 cells.
SY. Han, T. Anno, N. Fukuda, K. Nagao, T. Yanagita, J. Oleo Sci., 51: 243-250 (2002) [Publisher]

Feeding unsaponifiable compounds from rice bran oil dose not alter hepatic mRNA abundance for cholesterol metabolism-related proteins in hypercholesterolemic rats.
K. Nagao, M. Sato, M. Takenaka, M. Ando, M. Iwamoto, K. Imaizumi, Biosci. Biotech. Biochem., 65: 371-377 (2001) [PubMed]

A two-step mechanism for free cholesterol and phospholipid efflux from human vascular cells to apolipoprotein A-I.
PE. Fielding, K. Nagao, H. Hakamata, G. Chimini, CJ. Fielding, Biochemistry, 39: 14113-14120 (2000) [PubMed]

Superiority of dietary safflower oil over olive oil in lowering serum cholesterol and increasing hepatic mRNAs for LDL receptor and cholesterol 7alpha-hydroxylase in exogenously hypercholesterolemic (ExHC) rats.
M. Sato, S. Yoshida, K. Nagao, K. Imaizumi, Biosci. Biotech. Biochem., 64: 1111-1117 (2000) [PubMed]

Lymphatic lipid transport is not impaired in ageing rat intestine.
H. Hayashi, Y. Sato, S. Kanai, M. Masuda, M. Ohta, A. Funakoshi, K. Nagao, K. Imaizumi, K. Miyasaka, Mech. Ageing. Dev., 113: 219-225 (2000) [PubMed]

Application of the random arbitrary primed polymerase chain reaction differential display method to isolate genes of cholesterol metabolism-related proteins from rat liver.
M. Sato, S. Yoshida, K. Nagao, S. Nishizono, M. Kusaba, MC. Hung, I. Ikeda, K. Imaizumi, Biosci. Biotech. Biochem., 64: 1058-1060 (2000) [PubMed]

Effect of gemfibrozil on triacylglycerol synthesis and secretion by liver and lipoprotein lipase activity in adipose tissue of rats.
K. Nagao, M. Sakono, N. Nakayama, T. Hirakawa, K. Imaizumi, Comp. Biochem. Physiol., 124B: 289-294 (1999) [PubMed]

Ethanol-extracted soy protein isolate results in elevation of serum cholesterol in exogenously hypercholesterolemic rats.
WH. Ni, S. Yoshida, Y. Tsuda, K. Nagao, M. Sato, K. Imaizumi, Lipids, 34: 713-716 (1999) [PubMed]

The evaluation of disease pathopoiesis risks using the biomarkers. [Article in Japanese]
K. Nagao, KASEAA, 37: 394-395 (1999)

Gemfibrozil reduces non-high density lipoprotein cholesterol in exogenously hypercholesterolemic (ExHC) rats fed a high-cholesterol diet.
K. Nagao, S. Yoshida, H. Nakagiri, M. Sakono, M. Sato, K. Imaizumi, Comp. Biochem. Physiol., 120B: 579-586 (1998) [PubMed]

Supplementation of L-Arginine to casein-based diet alleviates atherosclerosis development in apolipoprotein E-deficient mice. [Article in Japanese]
W.H. Ni, T. Tsuda, M. Sato, K. Nagao, K. Imaizumi, Soy Protein Res., 1: 102-105 (1998)

Exogenously hypercholesterolemic rats, compared with their progenitor Sprague-Dawley rats, have altered mRNAs for cholesterol 7alpha-hydroxylase and low-density lipoprotein receptor and activities of cholesterol 7alpha-hydroxylase and acyl-CoA:cholesterol acyltransferase in the liver in response to dietary cholesterol.
K. Nagao, M. Sakono, H. Sakurai, M. Sato, K. Imaizumi, Comp. Biochem. Physiol., 118B: 949-955 (1997) [Publisher]

Comparison between dietary soybean protein and casein of the inhibiting effect on atherogenesis in the thoracic aorta of hypercholestroremic (ExHC) rats treated with experimental hypervitamin D.
M. Sakono, T. Fukuyama, WH. Ni, K. Nagao, HR. Ju, M. Sato, N. Sakata, H. Iwamoto, K. Imaizumi, Biosci. Biotech. Biochem., 61: 514-519 (1997) [PubMed]

Lymphatic transport of cholesterol in normocholesterolemic rats treated with pravastatin, an inhibitor of HMG-CoA reductase.
M. Sakono, T. Ibi, K. Nagao, I. Ikeda, K. Yamamoto, K. Imaizumi, Atherosclerosis, 124: 95-102 (1996) [PubMed]

Exogenous hypercholesterolemic rats, compared with their progenitor, Spargue-Dawley rats, promptly alter cholesterol metabolism in the liver and secrete cholesterol-rich particles in response to dietary cholesterol.
M. Sakono, H. Mori, K. Nagao, M. Sato, I. Ikeda, K. Yamamoto, K. Imaizumi, Comp. Biochem. Physiol., 113B: 803-808 (1996) [PubMed]

Low protein diets posttranscriptionally repress apolipoprotein B expression in rat liver.
M. Sato, K. Nagao, M. Sakono, H. Ogawa, K Yamamoto, K. Imaizumi, J. Nutr. Biochem., 7: 381-385 (1996) [Publisher]

The mechanism of cholesterol metabolism in exogenously hypercholesterolemic (ExHC) rats. [Article in Japanese]
K. Nagao, M. Sakono, K. Imaizumi, JCBL, 37: 195-198 (1995)

Repression of fat-dependent intestinal apo A-IV mRNA abundance by medium chain triacylglycerols and proteins, and elevation by carbohydrates of fat-dependent apo A-IV transport in sucling rat pups.
M. Sato, K. Nagao, T. Hayami, M. Sugano, K. Imaizumi, J. Nutr. Sci. Vitaminol., 41: 293-306 (1995) [PubMed]